Microenvironment Remodeling Micelles for Alzheimer's Disease Therapy by Early Modulation of Activated Microglia

• DOI: 10.1002/advs.201801586
• Publication Date: 2018-12-12T08:46:55Z
• Authors: Yifei Lu; Zhongyuan Guo; Yujie Zhang; Chao Li; Yu Zhang; Qin Guo; Qinjun Chen; Xinli Chen; Xi He; Lisha Liu; Chunhui Ruan; Tao Sun; Bin Ji; Weigen Lu; Chen Jiang
• Keywords: Crosstalk; Amyloid beta

Current strategies for Alzheimer's disease (AD) treatments focus on pathologies in the late stage of progression. Poor clinical outcomes are displayed due to irreversible damages caused by early microglia abnormality which triggers development before identical symptoms emerge. Based crosstalk between and brain microenvironment, a reactive oxygen species (ROS)-responsive polymeric micelle system (Ab-PEG-LysB/curcumin (APLB/CUR)) is reported normalize oxidative inflammatory microenvironment reeducate from an phase AD. Through β-amyloid (Aβ) transportation-mimicked pathway, micelles can accumulate into diseased regions exert synergistic effects polymer-based ROS scavenging cargo-based Aβ inhibition upon stimuli. This multitarget strategy exhibits gradual correction efficient neuroprotection, modulation, leading decreased plaque burdens consequently enhanced cognitive functions APPswe/PSEN1dE9 model mice. The results indicate that be exploited as target AD treatment their states controlled via modulation.