Cytocompatible, Injectable, and Electroconductive Soft Adhesives with Hybrid Covalent/Noncovalent Dynamic Network

• DOI: 10.1002/advs.201802077
• Publication Date: 2019-05-24T11:38:01Z
• Authors: Yong Xu; Panagiotis A. Patsis; Sandra Hauser; Dagmar Voigt; Rebecca Rothe; Markus Günther; Meiying Cui; Xuegeng Yang; Robert Wieduwild; Kerstin Eckert; Christoph Neinhuis; Teuku Fawzul Akbar; Ivan R. Minev; Jens Pietzsch; Yixin Zhang
• Keywords: Biocompatibility; Non-covalent interactions

Abstract Synthetic conductive biopolymers have gained increasing interest in tissue engineering, as they can provide a chemically defined electroconductive and biomimetic microenvironment for cells. In addition to low cytotoxicity high biocompatibility, injectability adhesiveness are important many biomedical applications but proven be very challenging. Recent results show that fascinating material properties realized with bioinspired hybrid network, especially through the synergy between irreversible covalent crosslinking reversible noncovalent self‐assembly. Herein, polysaccharide‐based hydrogel crosslinked reactions is reported. The exhibits rheological associated dynamic networks such self‐healing stress relaxation. Moreover, fine‐tuning network dynamics by varying covalent/noncovalent content incorporating polymers, resulting materials exhibit electroconductivity reliable adhesive strength, at similar range of clinically used fibrin glue. soft adhesives cytocompatibility 2D/3D cell cultures promote myogenic differentiation myoblast heparin‐containing shows biocompatibility immunocompetent mice, both topical application injectable materials. could utilities applications, area cardiovascular diseases wound dressing.