Biomimetic Nanotherapies: Red Blood Cell Based Core–Shell Structured Nanocomplexes for Atherosclerosis Management

• DOI: 10.1002/advs.201900172
• Publication Date: 2019-04-24T08:30:09Z
• Authors: Yi Wang; Kang Zhang; Xian Qin; Tianhan Li; Juhui Qiu; Tieying Yin; Junli Huang; Sean McGinty; Giuseppe Pontrelli; Jun Ren; Qiwei Wang; Wei Wu; Guixue Wang
• Keywords: PLGA

Cardiovascular disease is the leading cause of mortality worldwide. Atherosclerosis, one most common forms disease, characterized by a gradual formation atherosclerotic plaque, hardening, and narrowing arteries. Nanomaterials can serve as powerful delivery platforms for atherosclerosis treatment. However, their therapeutic efficacy substantially limited in vivo due to nonspecific clearance mononuclear phagocytic system. In order address this limitation, rapamycin (RAP)-loaded poly(lactic-