Slx5p‐Slx8p Promotes Accurate Chromosome Segregation by Mediating the Degradation of Synaptonemal Complex Components during Meiosis

• DOI: 10.1002/advs.201900739
• Publication Date: 2020-01-02T07:01:27Z
• Authors: Chao Liu; Haichao Zhao; Sai Xiao; Tingting Han; Yinghong Chen; Tong Wang; Yanjie Ma; Hui Gao; Zhiping Xie; Li‐Lin Du; Jian Li; Guoping Li; Wei Li
• Keywords: Synaptonemal complex; Crosstalk

Abstract Meiosis increases genetic diversity, yet the genome complement needs to be stable ensure offspring viability. Both small ubiquitin‐like modifier (SUMO) and ubiquitin have been reported participate in meiotic regulation, functions of SUMO‐ubiquitination crosstalk meiosis remain unclear. Here, it is that a SUMO‐targeted ligase, Slx8p, promotes accurate chromosome segregation during meiosis, since deletion SLX8 leads increased aneuploidy due defect synaptonemal complex (SC) component degradation. RING domain SUMO interacting motifs Slx8p are essential for progression maintaining spore viability, expression tetraubiquitin fused with partially rescues defects ‐deletion strain. Furthermore, Slx5p‐Slx8p can directly add SUMOylated Zip1p Ecm11p, forced degradation Ecm11p sporulation These findings provide mechanism SC disassembly reveal between SUMOylation ubiquitination facilitates by promoting meiosis.