Magnetically Active Cardiac Patches as an Untethered, Non‐Blood Contacting Ventricular Assist Device

• DOI: 10.1002/advs.202000726
• Publication Date: 2020-11-27T09:39:28Z
• Authors: Hongri Gu; Thibaud Bertrand; Quentin Boehler; Christophe Chautems; Nikolay V. Vasilyev; Bradley J. Nelson
• Keywords: Pulsatile flow

Abstract Patients suffering from heart failure often require circulatory support using ventricular assist devices (VADs). However, most existing VADs provide nonpulsatile flow, involve direct contact between the blood flow and device's lumen moving components, a driveline to connect an external power source. These design features lead complications such as gastrointestinal bleeding, device thrombosis, infections. Here, concept of magnetically active cardiac patches (MACPs) that can potentially function non‐blood contacting, untethered pulsatile inside magnetic actuationsystem is reported. The MACPs, which are composed permanent magnets 3D‐printed patches, attached epicardial surfaces, thus avoiding with flow. They powerful actuation assisting native pumping system. In ex vivo experiments on healthy pig's heart, it shown ejection fractions high 37% in left ventricle 63% right ventricle. Non‐blood eliminate risk serious associated devices, alternative solution for myocardial training therapy patients failure.