Bimodal Imaging‐Visible Nanomedicine Integrating CXCR4 and VEGFa Genes Directs Synergistic Reendothelialization of Endothelial Progenitor Cells

• DOI: 10.1002/advs.202001657
• Publication Date: 2020-11-09T08:25:21Z
• Authors: Bingbo Yu; Bing Dong; Jiang He; Hui Huang; Jinsheng Huang; Yong Wang; Jianwen Liang; Jianning Zhang; Yumin Qiu; Jun Shen; Xintao Shuai; Jun Tao; Wenhao Xia
• Keywords: Homing (biology); Nanocarriers; Endothelial progenitor cell

A major challenge to treat vascular endothelial injury is the restoration of endothelium integrity in which progenitor cells (EPCs) plays a central role. Transplantation EPCs as promising therapeutic means subject two interrelated processes, homing and differentiation vivo, thus lack either one may greatly affect outcome EPC-based therapy. Herein, polymeric nanocarrier applied for codelivery CXCR4 VEGFa genes simultaneously promote migration EPCs. Moreover, MRI T2 contrast agent SPION NIR dye Cy7.5 are also loaded into order track vivo. Based on synergistic effect codelivered genes, an improved reendothelialization achieved rat carotid denuded model. The results show potential this bimodal imaging-visible nanomedicine improve performance repairing arterial injury, push forward stem cell-based therapy cardiovascular disease.