Neutrophil Delivered Hollow Titania Covered Persistent Luminescent Nanosensitizer for Ultrosound Augmented Chemo/Immuno Glioblastoma Therapy

• DOI: 10.1002/advs.202004381
• Publication Date: 2021-07-02T01:57:48Z
• Authors: Yujie Li; Xucong Teng; Yongji Wang; Chunrong Yang; Xiuping Yan; Jinghong Li
• Keywords: Bispecific antibody

Glioblastoma (GBM) is the most malignant brain tumor with unmet therapeutic demand. The blood-brain-barrier (BBB) and heterogeneity limit treatment effectiveness of various interventions. Here, an ultrasound augmented chemo/immuno therapy for GBM using a neutrophil-delivered nanosensitizer, developed. sensitizer composed ZnGa2 O4 :Cr3+ (ZGO) core persistent luminescence imaging hollow sono-sensitive TiO2 shell to generate reactive oxygen species (ROS) controlled drug release. Immune checkpoint inhibitor (Anti-PD-1 antibody) trapped in interior porous ZGO@TiO2 paclitaxel (PTX) loaded liposome encapsulation form @ALP. Delivered by neutrophils (NEs), @ALP-NEs can penetrate through BBB accumulation. After intravenous injection, irradiation at sites initiates ROS generation from @ALP, leading destruction PTX anti-PD-1 antibody release kill tumors induce local inflammation, which in-turn attractes more migrate into sustained therapy. enhances survival rate bearing mice 0% 40% endows them long-term immuno-surveillance recurrence, providing new approach precision against other cancers.