Injectable Affinity and Remote Magnetothermal Effects of Bi‐Based Alloy for Long‐Term Bone Defect Repair and Analgesia

• DOI: 10.1002/advs.202100719
• Publication Date: 2021-05-20T09:40:14Z
• Authors: Yuanyuan He; Yu Zhao; Linlin Fan; Xuelin Wang; Minghui Duan; Hongzhang Wang; Xiyu Zhu; Jing Liu
• Keywords: metallic graft materials; non‐invasive wireless energy delivery; Male; 0303 health sciences; Osteoblasts; Science; hyperthermia analgesia; Q; injectable Bi alloy; Biocompatible Materials; Prostheses and Implants; bone defect repair; Bone and Bones; Rats; Rats, Sprague-Dawley; Disease Models, Animal; 03 medical and health sciences; Osseointegration; Alloys; Animals; Analgesia; Research Articles

Abstract As alternatives, metallic/nonmetallic bone graft materials play significant roles in defect surgery to treat external trauma or disease. However, date, there are rather limited long‐term implantable owning situ molding incapability of metallics and poor mechanical property nonmetallics. Here, Bi‐based low melting point alloy, with unique properties injectability, solid‐liquid phase transition, capability, biocompatibility, present obvious long‐lasting affinity as the excellent artificial bone‐substitute. It is particularly necessary out that targeted injected Bi alloy remains its original position for up 210 days without moving, well as, displays good osseointegration ability resolve repeated revision caused by losing repair material. Additionally, outstanding electrical thermal conductivity, an unconventional way using realize very beneficial hyperthermia analgesia via non‐invasive wireless energy delivery first proposed, which avoids adverse effects on remodeling inflicted traditional drugs. The significantly decreased expression pain sensitizing factor, such interleukin‐6, neuropeptide substance, transient receptor potential vanilloid 1 reveals mechanism analgesia. findings suggest combination therapy analgesia, owns far‐reaching clinical application value.