Platelet‐Like Fusogenic Liposome‐Mediated Targeting Delivery of miR‐21 Improves Myocardial Remodeling by Reprogramming Macrophages Post Myocardial Ischemia‐Reperfusion Injury

• DOI: 10.1002/advs.202100787
• Publication Date: 2021-06-17T10:34:04Z
• Authors: Haipeng Tan; Ya'nan Song; Jing Chen; Ning Zhang; Qiaozi Wang; Qiyu Li; Jinfeng Gao; Hongbo Yang; Zheng Dong; Xueyi Weng; Zhengmin Wang; Dili Sun; Wusiman Yakufu; Zhiqing Pang; Zheyong Huang; Junbo Ge
• Keywords: Reprogramming

Abstract Inflammatory modulations focusing on macrophage phenotype are promising candidates to promote better cardiac healing post myocardial ischemia‐reperfusion (MI/R) injury. However, the peak of monocyte/macrophage recruitment is later than time when enhanced permeability and retention effect disappears, which greatly increases difficulty reprogramming macrophages through systemic administration. Meanwhile, inability nanomaterials release their contents specific intracellular locations reasonable cellular internalization pathways another obstacle achieving reprogramming. Here, inspired by increase in circulating platelet‐monocyte aggregates patients′ post‐MI/R high efficiency fusogenic liposomes deliver cytoplasm target cells, a platelet‐like liposome (PLPs) constructed. Under coating PLPs, mesoporous silica nanospheres with payload miR‐21, an anti‐inflammatory agent, can be specifically delivered inflammatory monocytes blood circulation MI/R induced mice. Then it directly enters membrane fusion, thereby realizing reparative inflamed derived from it. In vivo administration resulting formula effectively preserve function mice undergone MI/R. Minimal invasiveness biological safety make this nano‐platform approach immunotherapy.