Neuregulin4 Acts on Hypothalamic ErBb4 to Excite Oxytocin Neurons and Preserve Metabolic Homeostasis

• DOI: 10.1002/advs.202204824
• Publication Date: 2023-04-15T03:51:11Z
• Authors: Yi Zhang; Yangyang Zhu; Jinghui Wang; Li Jin; Mingwei Guo; Liwei Chen; Lina Zhang; Yangyang Li; Baocheng Wan; Rong Zhang; Weiping Jia; Cheng Hu
• Keywords: Oxytocin receptor; Energy homeostasis

Neuregulin 4 (Nrg4) is an adipose tissue-enriched secreted factor that modulates glucose and lipid metabolism. Nrg4 closely associated with obesity preserves diet-induced metabolic disorders. However, the specific mechanisms via which regulates homeostasis remain incompletely understood. Here, this work finds receptor, ErbB4, highly expressed in hypothalamus, phosphorylation of hypothalamic ErbB4 reduced (DIO) mice. Peripheral can act on blood circulation excite neurons paraventricular nucleus hypothalamus (PVN). Central administration recombinant protein (rNrg4) reduces related disorders by influencing energy expenditure intake. Overexpression PVN protects against obesity, whereas its knock down oxytocin (Oxt) neuron accelerates obesity. Furthermore, Nrg4-ErbB4 signaling excites Oxt release, ablation considerably attenuates effect balance. These data suggest a key target Nrg4, partially explains multifaceted roles