Advanced Soft Robotic System for In Situ 3D Bioprinting and Endoscopic Surgery

• DOI: 10.1002/advs.202205656
• Publication Date: 2023-02-20T03:20:06Z
• Authors: Mai Thanh Thai; Phuoc Thien Phan; Hien Anh Tran; Chi Cong Nguyen; Trung Thien Hoang; James Davies; Jelena Rnjak‐Kova...; Hoang‐Phuong Phan; Nigel Hamilton Lo...; Thanh Nho Do
• Keywords: 3D bioprinting; Soft Robotics; Biofabrication

Three-dimensional (3D) bioprinting technology offers great potential in the treatment of tissue and organ damage. Conventional approaches generally rely on a large form factor desktop bioprinter to create vitro 3D living constructs before introducing them into patient's body, which poses several drawbacks such as surface mismatches, structure damage, high contamination along with injury due transport open-field surgery. In situ inside body is potentially transformational solution serves an excellent bioreactor. This work introduces multifunctional flexible (F3DB), features degree freedom soft printing head integrated robotic arm deliver multilayered biomaterials internal organs/tissues. The device has master-slave architecture operated by kinematic inversion model learning-based controllers. capabilities different patterns, surfaces, colon phantom are also tested composite hydrogels biomaterials. F3DB capability perform endoscopic surgery further demonstrated fresh porcine tissue. new system expected bridge gap field support future development advanced surgical robots.