Ultrasound‐Responsive Oxygen‐Carrying Pollen for Enhancing Chemo‐Sonodynamic Therapy of Breast Cancer

• DOI: 10.1002/advs.202300456
• Publication Date: 2023-05-17T01:54:34Z
• Authors: Baojie Wen; Danqing Huang; Chuanhui Song; Jingyang Shan; Yuanjin Zhao
• Keywords: Sonodynamic therapy

The tumor-suppressing efficacy of either chemotherapeutics or gaseous drugs has been confirmed in treating the triple negative breast cancer (TNBC), while single treatment is usually dissatisfactory. Herein, a novel ultrasound responsive natural pollen delivery system presented to simultaneously load and for synergistic TNBC. hollow structure grains carries oxygen-enriched perfluorocarbon (PFC), porous spinous process adsorbs chemotherapeutic drug doxorubicin (DOX) (PO/D-PGs). Ultrasound can trigger oxygen release from PFC excite DOX, which not only but also sonosensitizer, realize chemo-sonodynamic therapy. PO/D-PGs are demonstrated effectively enhance concentration increase production reactive species presence low-intensity ultrasound, synergistically enhancing tumor killing ability. Thus, therapy based on ultrasound-facilitated significantly enhances antitumor effect mouse TNBC model. It believed that proposed cross-state microcarrier be used as an effective strategy