Blockage of Osteopontin‐Integrin β3 Signaling in Infrapatellar Fat Pad Attenuates Osteoarthritis in Mice

• DOI: 10.1002/advs.202300897
• Publication Date: 2023-05-23T08:44:18Z
• Authors: Bingyang Dai; Yuwei Zhu; Xu Li; Zuru Liang; Shunxiang Xu; Shian Zhang; Zhe Zhang; Shanshan Bai; Wenxue Tong; Mingde Cao; Ye Li; Xiaobo Zhu; Wei Liu; Yuantao Zhang; Liang Chang; Patrick Shu‐hang ...; Kevin Ki‐wai Ho; Jiankun Xu; To Ngai; Ling Qin
• Keywords: Infrapatellar fat pad; Osteopontin; Fat pad

Abstract The knowledge of osteoarthritis (OA) has nowadays been extended from a focalized cartilage disorder to multifactorial disease. Although recent investigations have reported that infrapatellar fat pad (IPFP) can trigger inflammation in the knee joint, mechanisms behind role IPFP on OA progression remain be defined. Here, dysregulated osteopontin (OPN) and integrin β 3 signaling are found specimens both human mice. It is further demonstrated IPFP‐derived OPN participates progression, including activated matrix metallopeptidase 9 chondrocyte hypertrophy fibrosis. Motivated by these findings, an injectable nanogel fabricated provide sustained release siRNA Cd61 ( RGD− Nanogel/siRNA ) targets integrins. Nanogel possesses excellent biocompatibility desired targeting abilities vitro vivo. Local injection robustly alleviates degeneration, suppresses advancement tidemark, reduces subchondral trabecular bone mass Taken together, this study provides avenue for developing therapy mitigate via blocking OPN‐integrin IPFP.