Modular Hydrogel Vaccine for Programmable and Coordinate Elicitation of Cancer Immunotherapy

• DOI: 10.1002/advs.202301789
• Publication Date: 2023-05-24T08:07:52Z
• Authors: Panpan Ji; Wenqi Sun; Siyan Zhang; Yuqi Xing; Chen Wang; Mengying Wei; Qiuyun Li; Gang Ji; Guodong Yang
• Keywords: Cancer Immunotherapy

Abstract Immunotherapy holds great promise for the treatment of malignant cancer. However, lack sufficient tumor neoantigens and incomplete dendritic cell (DC) maturation compromise efficacy immunotherapy. Here, a modular hydrogel‐based vaccine capable eliciting powerful sustained immune response is developed. Briefly, CCL21a Exo GM‐CSF+Ce6 (tumor cell‐derived exosomes with granulocyte‐macrophage colony‐stimulating factor (GM‐CSF) mRNA encapsulated inside sonosensitizer chlorin e6 (Ce6) incorporated in surface) are mixed nanoclay gelatin methacryloyl, forming hydrogel designated as CCL21a/Exo @nanoGel. The engineered releases GM‐CSF time gap. earlier released diverts tumor‐draining lymph node (TdLN) metastatic cells to hydrogel. Consequently, trapped hydrogel, turn, engulf Ce6‐containing thus eradicated by sonodynamic therapy (SDT), serving antigen source. Later, together remnant CCL21a, produced engulfing continuously recruits provokes DCs. With two programmed modules, efficiently inhibits growth metastasis via diverting TdLN cancer killing cells, prolonged immunotherapy an orchestrated manner. strategy would open avenue