IFI27 Integrates Succinate and Fatty Acid Oxidation to Promote Adipocyte Thermogenic Adaption

• DOI: 10.1002/advs.202301855
• Publication Date: 2023-08-07T02:27:17Z
• Authors: Xuan Cui; Haojie Liu; Ting Shi; Qingwen Zhao; Feiyan Li; Wenjing Lv; Chao Yu; Haiyan Huang; Qi‐Qun Tang; Dongning Pan
• Keywords: SDHB

Mitochondria are the pivot organelles to control metabolism and energy homeostasis. The capacity of mitochondrial metabolic adaptions cold stress is essential for adipocyte thermogenesis. How brown adipocytes keep fitness upon a challenge cold-induced oxidative has not been well characterized. This manuscript shows that IFI27 plays an important role in cristae morphogenesis, keeping intact succinate dehydrogenase (SDH) function active fatty acid oxidation sustain thermogenesis adipocytes. protein interaction map identifies SDHB HADHA as its binding partners. physically links chaperone TNF receptor associated 1 (TRAP1), which shields from damage-triggered degradation. Moreover, increases hydroxyacyl-CoA trifunctional multienzyme complex subunit alpha (HADHA) catalytic activity β-oxidation pathway. reduced SDH level Ifi27-knockout fat results impaired oxygen consumption defective Thus, novel regulator