Revealing Low Amplitude Signals of Neuroendocrine Cells through Disordered Silicon Nanowires‐Based Microelectrode Array

• DOI: 10.1002/advs.202301925
• Publication Date: 2023-06-26T02:09:17Z
• Authors: Francesco Maita; Luca Maiolo; Ivano Lucarini; Josè Ignacio Del ...; Antonio Sciortino; Mario Ledda; Valentina Mussi; Antonella Lisi; Annalisa Convertino
• Keywords: Multielectrode array

Abstract Today, the key methodology to study in vitro or vivo electrical activity a population of electrogenic cells, under physiological pathological conditions, is by using microelectrode array (MEA). While significant efforts have been devoted develop nanostructured MEAs for improving electrophysiological investigation neurons and cardiomyocytes, data on recording from neuroendocrine cells with MEA technology are scarce owing their weaker signals. Disordered silicon nanowires (SiNWs) developing that, combined customized acquisition board, successfully capture signals generated corticotrope AtT‐20 as function extracellular calcium (Ca 2+ ) concentration reported. The recorded show shape that clearly resembles action potential waveform suggesting natural membrane penetration SiNWs. Additionally, generation synchronous observed high Ca content indicates occurrence collective behavior cell population. This extends usefulness communication pituitary gland, crucial controlling several essential human functions, provides new perspectives excitable cells.