Magnetic Nanoparticles and Methylprednisolone Based Physico‐Chemical Bifunctional Neural Stem Cells Delivery System for Spinal Cord Injury Repair

• DOI: 10.1002/advs.202308993
• Publication Date: 2024-03-22T08:51:08Z
• Authors: Wencan Zhang; Mingshan Liu; Jie Ren; Shuwei Han; Xiaolong Zhou; Dapeng Zhang; Xianzheng Guo; Haiwen Feng; Lei Ye; Shiqing Feng; Xizi Song; Lin Jin; Zhijian Wei
• Keywords: spinal cord injury repair; 0301 basic medicine; magnetic nanoparticles guidance; Science; Q; Cell Differentiation; Methylprednisolone; Mice; Disease Models, Animal; 03 medical and health sciences; Neural Stem Cells; Animals; neural stem cell transplantation; mechanical stimulation; Magnetite Nanoparticles; functional neurogenesis; Research Articles; Spinal Cord Injuries; Stem Cell Transplantation

Abstract Neural stem cells (NSCs) transplantation is an attractive and promising treatment strategy for spinal cord injury (SCI). Various pathological processes including the severe inflammatory cascade difficulty in stable proliferation differentiation of NSCs limit its application translation. Here, a novel physico‐chemical bifunctional neural delivery system containing magnetic nanoparticles (MNPs methylprednisolone (MP) designed to repair SCI, former regulates through mechanical stimulation chronic phase, while latter alleviates response acute phase. The releases MP promote microglial M2 polarization, inhibit M1 reduce neuronal apoptosis. Meanwhile, tend differentiate into functional neurons with generated by MNPs static field, which related activation PI3K/AKT/mTOR pathway. SCI mice achieve better recovery after receiving via system, has milder inflammation, higher number microglia, more neurons, axonal regeneration. Together, this combined physical chemical drug therapy demonstrated be effective, provides new insights clinical transformation repair.