YBX1‐Mediated DNA Methylation‐Dependent SHANK3 Expression in PBMCs and Developing Cortical Interneurons in Schizophrenia (Adv. Sci. 20/2023)

• DOI: 10.1002/advs.202370132
• Publication Date: 2023-07-26T08:33:28Z
• Authors: Peiyan Ni; Chuqing Zhou; Sugai Liang; Youhui Jiang; Dongxin Liu; Zhicheng Shao; Haneul Noh; Liansheng Zhao; Yang Tian; Chengcheng Zhang; Jinxue Wei; Xiaojing Li; Hua Yu; Rongjun Ni; Xueli Yu; Xueyu Qi; Yamin Zhang; Xiaohong Ma; Wei Deng; Wanjun Guo; Qiang Wang; Pak C. Sham; Sangmi Chung; Tao Li

Developing Cortical Interneuronsin Schizophrenia The elusive human brain is much like the unattainable sun, and there is no directly feasible approach to understand how the brain is disturbed during the development of schizophrenia. As the shimmering sun's reflection in the water, brain organoid provides an accessible bridge to explore the mysteries of the human brain. In article number 2300455, Peiyan Ni, Chuqing Zhou, Sangmi Chung, and co‐workers confirm the hypermethylation and dysregulated expression of SHANK3 in schizophrenia patient‐derived cortical interneurons‐rich organoid, which serves as a bridge to explore the pathological changes in the brain by measuring SHANK3 methylation in peripheral blood mononuclear cells as a biomarker. [Image: see text]