Sonosynthetic Cyanobacteria Oxygenation for Self‐Enhanced Tumor‐Specific Treatment

• DOI: 10.1002/advs.202400251
• Publication Date: 2024-06-13T04:43:34Z
• Authors: Zhenyu Yang; Xiu Shen; Junyi Jin; Xiaoyan Jiang; Wenqi Pan; Chenyao Wu; Dehong Yu; Ping Li; Wei Feng; Yu Chen
• Keywords: Tumor Hypoxia; Oxidizing agent

Abstract Photosynthesis, essential for life on earth, sustains diverse processes by providing nutrition in plants and microorganisms. Especially, photosynthesis is increasingly applied disease treatments, but its efficacy substantially limited the well‐known low penetration depth of external light. Here, ultrasound‐mediated reported enhanced sonodynamic tumor therapy using organic sonoafterglow (ultrasound‐induced afterglow) nanoparticles combined with cyanobacteria, demonstrating proof‐of‐concept sonosynthesis (sonoafterglow‐induced photosynthesis) cancer therapy. Chlorin e6, a typical small‐molecule chlorine, formulated into to stimulate cyanobacteria sonosynthesis, which serves three roles, i.e., overcoming tissue‐penetration limitations light sources, reducing hypoxia, acting as sonosensitizer vivo suppression. Furthermore, sonosynthetic oxygenation suppresses expression hypoxia‐inducible factor 1α, leading reduced stability downstream SLC7A11 mRNA, results glutathione depletion inactivation peroxidase 4, thereby inducing ferroptosis cells. This study not only broadens scope microbial nanomedicine also offers distinct direction sonosynthesis.