Modeling the Effects of Protracted Cosmic Radiation in a Human Organ‐on‐Chip Platform

• DOI: 10.1002/advs.202401415
• Publication Date: 2024-07-05T06:00:16Z
• Authors: Daniel Naveed Tav...; Trevor R. Nash; Youngbin Kim; Pamela L. Graney; Martin Liberman; Sharon Fleischer; Roberta I. Lock; Aaron O'Donnell; Leah Andrews; Derek Ning; Keith Yeager; Andrew Harken; Naresh Deoli; Sally A. Amundson; Guy Garty; Kam W. Leong; David J. Brenner; Gordana Vunjak‐No...
• Keywords: Space Radiation

Abstract Galactic cosmic radiation (GCR) is one of the most serious risks posed to astronauts during missions Moon and Mars. Experimental models capable recapitulating human physiology are critical understanding effects on organs developing radioprotective measures against space travel exposures. The systemic studied using a multi‐organ‐on‐a‐chip (multi‐OoC) platform containing engineered tissue bone marrow (site hematopoiesis acute damage), cardiac muscle chronic damage) liver metabolism), linked by vascular circulation with an endothelial barrier separating individual chambers from perfusate. Following protracted neutron radiation, damaging component in deep space, greater deviation function observed as compared same cumulative dose delivered acutely. Further, characterizing (eBM)‐derived immune cells circulation, 58 unique genes specific dosing identified, acutely irradiated healthy tissues. It propose that this bioengineered allows studies responses extended exposure “astronaut‐on‐a‐chip” model can inform for mitigating injury.