Interfacial Denaturation at the Droplet Simplifies the Formation of Drug‐Loaded Protein Nanocapsules to Enhance Immune Response of Cells

• DOI: 10.1002/advs.202403668
• Publication Date: 2024-07-08T07:30:10Z
• Authors: Sharafudheen Pott...; Jinhong Kang; Michael Fichter; Kai Robert Speth; Volker Mailänder; Katharina Landfester
• Keywords: Nanocapsules; Denaturation (fissile materials)

Nanocapsules enable multicomponent encapsulation of therapeutic cargoes with high content and efficiency, which is vital for cancer immunotherapy. In the past, chemical crosslinking used to synthesize nanocapsules, can impede regulatory approval process. Therefore, a new class protein nanocapsules developed by eliminating need utilizing denaturation through process that referred as "baking at droplet interface". Such antigens incorporated in shell combination encapsulated drugs showed an enhancement immune response cells.