Chronic Exposure to Bioaerosols in PM2.5 from Garbage Stations Accelerates Vascular Aging via the NF‐κB/NLRP3 Pathway

• DOI: 10.1002/advs.202404142
• Publication Date: 2024-10-22T10:54:38Z
• Authors: Peier Chen; Xiaodong Ning; Weijing Feng; Yajing Li; Guoqin Chen; Xu Shi; YuXuan Pan; Xueqin Shi; Yafang Xiao; Yuhua Liu; Guoxia Zhang; Feiran Zhou; Caiwen Ou
• Keywords: Indoor bioaerosol; Quartile; Bioaerosol; Senescence

Abstract The fine particulate matter (PM2.5) in air pollution is a critical risk factor influencing human health. Our study included 8144 participants and showed that the of major adverse cardiovascular events increases by 35% (HR, 1.35; 95% CI, 1.14–1.60) for with highest quartile to PM2.5 exposure as compared those lowest quartile. Bioaerosols, an important environmental PM2.5, can induce systemic chronic inflammation leading vascular aging. Thus, effects bioaerosols are investigated from household garbage stations on aging, underlying mechanisms explored. In vivo, upregulated senescence marker expression levels while causing dysfunction remodeling. vitro, bioaerosol induced decreased proliferation, G0/G1 arrest, impaired migration umbilical vein endothelial cells (HUVECs). Furthermore, single bacterium (AS22a) community was isolated demonstrated it inflammatory factors accelerated cell aging activating NF‐κB/NLRP3 signaling pathway, which may serve primary mechanism PM2.5. These findings suggest high adversely affect