Biomimetic Liver Lobules from Multi‐Compartmental Microfluidics

• DOI: 10.1002/advs.202406573
• Publication Date: 2024-09-19T10:21:52Z
• Authors: Danqing Huang; Zhuhao Wu; Ji Wang; Jinglin Wang; Yuanjin Zhao
• Keywords: Biomimetics

Engineered liver lobule is highly practical in hepatic disease treatment, while constructing a 3D biomimetic with heterogeneous architecture on large scale challenging. Here, inspired by the natural architectural construction of lobules, lobules are proposed coaxially through-pores for nutrient exchange via microfluidic technology. This multi-channel chip made parallelly installing capillaries. Sodium alginate (Alg) pumped through its central channel, Ca