Sugar Functionalized Collagen Material for Local Modulation of Innate Immunity

• DOI: 10.1002/advs.202415364
• Publication Date: 2025-05-24T11:25:46Z
• Authors: Francesca Taraballi; Claudia Corbo; Julia Enterria‐Ro...; John Otto Martinez; Silvia Minardi; Laura Pandolfi; Xing Wang; Ennio Tasciotti; Kavindra V. Singh; Cesar A. Arias; Bruna Corradetti

Abstract Small alterations during the early stages of innate immune response to an implant can drive large changes in adaptive immunity. Biomaterials for regenerative purposes be engineered modulate this beneficial ways. This study presents innovative patch designed and functionalized target immunity at site. Mannose moieties are incorporated into collagen patches, resulting a technology called Local Immunotuning Patch (LIP), directly interact with antigen presenting cells through their mannose receptor. In vitro, LIP shows anti‐inflammatory effects on bone marrow‐derived macrophages inhibitory properties even methicillin‐resistant bacterial strains. Subcutaneous implantation mice reveals that modulates multiple pathways related immunity, underscoring its role shaping immune‐engineered environment around implant. These findings highlight potential strategy control foreign body reaction site, making it applicable various uses, including wound healing surgical infection reconstructive procedures.