Lymphocyte‐Activation Gene 3 Facilitates Pathological Tau Neuron‐to‐Neuron Transmission (Adv. Sci. 16/2024)

• DOI: 10.1002/advs.202470092
• Publication Date: 2024-04-24T08:06:26Z
• Authors: Chan Chen; Ramhari Kumbhar; Hu Wang; Xiuli Yang; Kundlik Gadhave; Cyrus Rastegar; Yasuyoshi Kimura; Adam Behensky; Sumasri Kotha; Grace Kuo; Sruthi Katakam; Deok Jeong; Liang Wang; Anthony Wang; Rong Chen; Shu Zhang; Lingtao Jin; Creg J. Workman; Dario A. A. Vignali; Olga Pletinkova; Hongpeng Jia; Weiyi Peng; David W. Nauen; Philip C. Wong; Javier Redding‐Ochoa; Juan C. Troncoso; Mingyao Ying; Valina L. Dawson; Ted M. Dawson; Xiaobo Mao

Tau preformed Fibrils The pathological tau transmission mechanism was elusive. Despite known neuronal uptake pathways, tau‐fibril‐specific receptor‐mediated uptake routes remained obscure, akin to the “maze”. In article number 2303775, Valina L. Dawson, Ted M. Dawson, Xiaobo Mao, and co‐workers unveil a novel pathway: spotlighting Lag3 (red), a neuronal surface protein, acts as a major tau fibril receptor facilitating subsequent uptake and propagation in neurons. This discovery elucidates the tau fibril entry “maze” via Lag3. [Image: see text]