Amino Acid‐Sensing Neurons in the Anterior Piriform Cortex Control Brown Adipose Tissue Thermogenesis

• DOI: 10.1002/advs.202502421
• Publication Date: 2025-04-30T23:59:36Z
• Authors: Peixiang Luo; Kexin Tong; Yeting Gan; Min Tang; Yuguo Niu; Kan Liu; Shihong Ni; Shangming Wu; Xiaoxue Jiang; Haizhou Jiang; Fei Xiao; Shanghai Chen; Wei Lv; Xiaoying Li; Feixiang Yuan; Feifan Guo
• Keywords: Piriform cortex

Amino acid sensing in the central nervous system plays a key role regulating energy homeostasis. The anterior piriform cortex (APC) has been implicated amino deficiency and rapidly inducing an aversive response. However, precise types of neurons involved whether they possess additional metabolic regulatory functions remain to be elucidated. study reveals that corticotropin-releasing hormone (CRH) APC (APCCRH neurons) are activated by leucine-deficient diet modulate brown adipose tissue thermogenesis regulate body temperature response leucine deprivation. findings reveal APCCRH sensitive leucine-deprivation signaling, with general control nonderepressive-2 playing essential enhancing their intrinsic excitability. Furthermore, project into known hypothalamic thermoregulatory region lateral hypothalamus, APCCRH-lateral hypothalamus circuits mediate deprivation-induced thermogenesis. Additionally, it is observed thermogenic regulation contributes maintenance under cold exposure. Collectively, identify population leucine-sensing neurons, signals subsequent contribution