Dual Roles of α,β‐Unsaturated Oximes in Copper Catalyzed [3+3] Cyclization: Construction of 2,4,6‐Trisubstituted Pyridines

• DOI: 10.1002/ajoc.201800318
• Publication Date: 2018-05-25T15:11:45Z
• Authors: Jianming Liu; Shufang Zhao; Xuyang Yan; Zhixian Wang; Yanyan Zhang; Peizheng Zhao; Wenhan Fang; Kelei Zhuo; Yuanyuan Yue
• Keywords: Dual role; Michael reaction

Abstract A new approach to generate 2,4,6‐trisubstituted pyridines was successfully developed based on the cyclization of α,β‐unsaturated oximes catalyzed by copper(I). The method takes advantage inherent properties pyridines. In this transformation, play dual roles in formation nucleophilic copper(II) enamide and as acceptor Michael addition.