Nasal lavage levels of granulocyte‐macrophage colony‐stimulating factor and chronic nasal hypereosinophilia

• DOI: 10.1002/alr.21519
• Publication Date: 2015-03-27T22:07:50Z
• Authors: Eugenio De Corso; Silvia Baroni; Daniela Lucidi; Mariapina Battista; Matteo Romanello; Chiara Autilio; Renato Morelli; Walter Di Nardo; Giulio Cesare Pas...; Bruno Sergi; Francesco Bussu; Anna Rita Fetoni; Cecilia Zuppi; Gaetano Paludetti
• Keywords: Hypereosinophilia; Nasal Lavage; Nasal Polyps; Rhinology

Background The aim of the present study was to measure levels granulocyte‐macrophage colony‐stimulating factor (GM‐CSF) in nasal lavage patients affected by chronic eosinophilic sinonasal inflammation clarify relationship with tissue infiltration and clinical features. Methods Between November 2012 June 2013, we selected 70 (average age 41.8 years) who were classified into following groups: persistent allergic rhinitis (group 1), noninfectious non‐allergic eosinophilia syndrome 2) rhinosinusitis polyps 3). Finally, enrolled 20 healthy subjects as controls 4). All underwent symptoms score questionnaire based on a visual analogue scale, endoscopy and/or computed tomography (CT) scan, allergy testing. Nasal cytology scraping mucosa GM‐CSF assays performed all subjects. Results Detectable found 34 (48.57%) patients, an average concentration 2.67 ± 0.8 pg/mL, whereas only 1 individuals showed detectable levels. Eosinophil significantly higher compared those undetectable (49.4% vs 39.2%, respectively; p < 0.05). Furthermore, significant weakly‐moderate correlation between percentage eosinophil ( Correlation symptom scores group 2, which concentrations groups 3 (2.9 pg/mL 1.6 1.8 Conclusion Our data confirm that is more frequently lavages than controls. Statistical analyses revealed mucosa.