A validated model for the 22‐item Sino‐Nasal Outcome Test subdomain structure in chronic rhinosinusitis

• DOI: 10.1002/alr.22025
• Publication Date: 2017-10-13T16:42:40Z
• Authors: Allen L. Feng; Nicholas C. Wesely; Lloyd P. Hoehle; Katie M. Phillips; Alisa Yamasaki; Adam P. Campbell; Luciano L. Gregorio; Thomas E. Killeen; David S. Caradonna; Josh C. Meier; Stacey T. Gray; Ahmad R. Sedaghat
• Keywords: Chronic Rhinosinusitis; Exploratory factor analysis

Background Previous studies have identified subdomains of the 22‐item Sino‐Nasal Outcome Test (SNOT‐22), reflecting distinct and largely independent categories chronic rhinosinusitis (CRS) symptoms. However, no study has validated subdomain structure SNOT‐22. This aims to validate existence underlying symptom SNOT‐22 using confirmatory factor analysis (CFA) develop a model that practitioners researchers can use describe CRS symptomatology. Methods A total 800 patients with were included into this cross‐sectional (400 from Boston, MA, 400 Reno, NV). Their responses analyzed exploratory (EFA) determine number subdomains. CFA was performed measurement for along various tests validity goodness fit. Results EFA demonstrated 4 factors reflecting: sleep, nasal, otologic/facial pain, emotional symptoms (Cronbach's alpha, >0.7; Bartlett's test sphericity, p < 0.001; Kaiser‐Meyer‐Olkin >0.90), geographic locale. The corresponding excellent measures fit (root mean square error approximation, <0.06; standardized root residual, <0.08; comparative index, >0.95; Tucker‐Lewis >0.95) construct (heterotrait‐monotrait [HTMT] ratio, <0.85; composite reliability, >0.7), again Conclusion 4‐subdomain (reflecting CRS) as most appropriate calculate scores different regions CFA.