Depressive symptoms in patients referred for clinical amyloid PET imaging

• DOI: 10.1002/alz.057665
• Publication Date: 2021-12-31T11:50:26Z
• Authors: Flavia Loreto; Anna Fitzgerald; Mara Golemme; Zarni Win; Neva Patel; Stephen Gunning; Anastasia Gontsarova; Angus Kennedy; Paul Edison; Christopher J Car...; Richard J Perry; Paresh A Malhotra
• Keywords: Depression; History of depression; Etiology; Atypical depression

Abstract Background The clinical use of amyloid‐PET imaging (API) is guided by a set published appropriate criteria (Johnson et al., 2013). Patients meeting these have suspected Alzheimer’s Disease (AD) accompanied an atypical presentation leading to substantial diagnostic uncertainty. Previous large‐cohort studies investigated this population from standpoint, looking at the impact using elucidate aetiology impairment. However, data concerning their phenotypes lacking. In study, we prevalence depression and its association with pathology in Memory Clinic patients who received API. Method We reviewed records 185 older adults (mean age 67.09±9.35, 49% females) were assessed our between January 2017 June 2019 Referral followed multidisciplinary was line criteria. categorised as ‘D+’, history depression, if they had previous diagnosis and/or depressive symptoms. Overall compared cohort data. Amyloid‐PET results (positive versus negative) D+ D‐ (without depression) groups. patients, determined onset status Result Of 98 (53%) depression. these, 89 individuals ongoing symptoms time referral 59 them on antidepressants. mean 58.25(±12.25) years. Depression considerably higher than that generally seen memory clinics (20%; Knapskog 2014) healthy (19%; McDougall al.,2017). not associated (%positive: 39.8%, 50.6%, χ 2 (1)=2.16 p=.14), (mean±SD: 66.47±9.03 years, 67.79±9.71 t(183)=‐.95 p=.342), or sex (%female: 44.9%, 52.9%, (1)=.1.17 p=.304). Conclusion high referred for independent presence absence pathology. may be one key contributors uncertainty group.