Inverse relationship between education and amyloid burden in individuals with subjective cognitive decline plus and mild cognitive impairment

• DOI: 10.1002/alz.064097
• Publication Date: 2023-06-16T11:19:31Z
• Authors: Merle C. Hönig; Camilla Caprioglio; Lyduine E. Collij; Giovanni B Frisoni; Frederik Barkhof; Gill Farrar; Philip Scheltens; Julien Delrieu; Jose Luis Molinuevo; Oriol Grau‐Rivera; Zuzana Walker; Agneta K Nordberg; Jean‐François Dem...; Andrew W. Stephens; Mark R Battle; Christopher Buckley; Juan Domingo Gispert; Frank Jessen; Daniele Altomare; Alexander Drzezga
• Keywords: Cognitive Decline; Neuropathology

Abstract Background Higher educated patients with MCI can tolerate more neuropathology than lower similar clinical impairment. It is not known whether this observation also accounts for potential preclinical stages of AD, namely subjective cognitive decline plus (SCD+). Method Data 197 SCD+ individuals, 227 and 157 AD were included, which collected as part the AMYPAD‐DPMS cohort (https://amypad.eu/). First, median education in years was computed across AD‐spectrum groups each 8 European sites. Next, using a split, SCD+, separately categorized into higher group, excluding subjects education. Afterwards, matched age, sex function (MMSE) propensity score matching R, leading to following sample (low/high education): 54/54 70/81 56/65 patients. Global amyloid load compared between Centiloid (CL) information derived from Flutemetamol Florbetaben PET scans. To confirm results stringent group comparison, partial correlations CL values correcting tracer type performed group. All analyses conducted SPSS 28 significance level set p < .05. Result presented significantly (p <. 001) (M(CL) = 16.48) 32.17), whereas opposite effect .046) observed presenting greater 57.08) 41.74). No difference found Results further confirmed by correlation approach unmatched yielding negative association (r ‐.159, .027) positive .153, .022). Conclusion These indicate that sensitivity early accumulation may possibly increase support compensatory mechanisms against burden.