Neuropsychiatric Symptoms and Alzheimer’s Disease Risk Differences across Racial and Ethnic Groups

• DOI: 10.1002/alz.075870
• Publication Date: 2023-12-25T13:42:35Z
• Authors: Victoria V Nguyen; Esteban G Escobar; Daniel L Gillen; David L Sultzer
• Keywords: Odds

Abstract Background Neuropsychiatric symptoms (NPS) emerging after the age of 50 may be a risk factor or an early clinical expression AD dementia. Mild Behavioral Impairment (MBI) is syndrome new‐onset and persistent NPS in older adults either with without cognitive impairment. context race ethnicity have not been studied influence biology culture on unknown. Method Participants over 60 ranging from cognitively normal to mild (N = 17,491) National Alzheimer’s Coordinating Center were categorized for MBI status (yes/no) using Inventory‐Questionnaire (NPI) scores published algorithm. prevalence across White non‐Hispanics, Hispanics, African Americans, Asians was compared multivariable logistic regression adjustment priori specified confounding factors including diagnostic group, age, sex, other relevant factors. Among negative participants at baseline, Cox proportional hazards model also fit estimate relative progression race/ethnicity groups. Result After adjustment, Hispanics estimated 2‐fold higher odds when non‐Hispanics (OR, 2.03; 95% CI, 1.65‐2.50; p<0.001). In contrast, Americans less likely than 0.79; 0.68‐0.92; p<0.003). The significantly among men women 1.28; 1.16‐1.41; prospective analysis, 26% lower progressing (RR, 0.74; 0.65‐0.84; Conclusion These findings suggest there are racial/ethnic differences had likelihood having MBI, while non‐Hispanics. Future research warranted investigate potential biological features cultural such as differential perception that explain these differences.