Alzheimer´s Disease initial cognitive profile in an Argentinian cohort of individuals with Down Syndrome

• DOI: 10.1002/alz.080611
• Publication Date: 2023-12-25T13:42:35Z
• Authors: Lucia Pertierra; Giulia Solange Clas; Fernanda Tapajoz; Belén Helou; Nahuel Magrath Gu...; Yanina Bérgamo; Silvia Vazquez; Gustavo Sevlever; Ricardo Francisco...; Ezequiel Surace
• Keywords: Memory clinic; Cognitive Decline

Abstract Background Down Syndrome [DS] is the most frequent cause of genetic developmental and intellectual disability. The lifetime risk Alzheimer’s Disease [AD] in people with DS more than 90%, an earlier age onset general population. There ongoing debate whether there are significant differences dementia presentation specific context DS, some studies suggesting a predominantly frontal phenotype behavioural symptoms others amnestic presentation. aim this study was to characterize initial cognitive profile AD cohort Argentinian adults DS. Method Adults prodromal or established who were part IASDA (Argentinian initiative for AD) spontaneusly attended our Memory Clinic included. Initial determined by semi‐structured interview conducted neurologist subject, their family caregivers. Result Sixteen Fifty‐six percent (n = 9) males. Mean 51 yo (42‐59 yo). Sixty‐two 10) had premorbid moderate disability [DI], 25% 4) severe DI 13% 2) mild DI. clinical diagnosis AD, remaining individuals clinically dementia. Fifty 8) positive amiloid biomarkers (determined cerebral PiB‐PET cerebrospinal fluid levels Aβ42, phosphorylated‐tau total‐tau), while subjects did not undergo biomarker assessment. Due impairment, language impairment and/or DI, only completed neuropsychological testing (CAMDEX‐DS, Cued Recall Task). charactirized as (single‐domain multiple‐domain amnestic) 81% 13) cohort. Only non‐amnestic syndromes, one case (6%) syndrome uncertain. Conclusion Amnestic impariment small Latin American