APOE4 Carriers with Perivascular Spaces Exhibit Altered Cerebral Blood Flow

• DOI: 10.1002/alz.081752
• Publication Date: 2023-12-25T07:16:42Z
• Authors: Arunima Kapoor; Shubir Dutt; John Paul M Alitin; Jung Yun Jang; Aimée Gaubert; Amy Nguyen; Isabel J Sible; Anisa J Marshall; Fatemah Shenasa; Allie Engstrom; David Bradford; Kathleen E. Rodgers; Xingfeng Shao; Danny J.J. Wang; Daniel A. Nation
• Keywords: Perivascular space

Abstract Background Perivascular spaces (PVS) are fluid‐filled surrounding arterioles, capillaries and venules in the brain, which support metabolic waste clearance. Enlarged PVS associated with increased dementia risk. Changes arterial pulsatility hypothesized to be accumulation of toxic solutes widening. However, few prior studies have examined whether cerebral blood flow (CBF) is linked PVS. Method Independently living older adults (N = 60, mean age 68.1 years; SD 7.5; range 55‐88 30.0% male) free or clinical stroke were recruited from community underwent brain MRI venipuncture. Pseudo‐continuous spin labeling was utilized determine CBF gray matter (mL/100g tissue/min). Regional values determined for regions interest. qualitatively scored basal ganglia (BG), centrum semiovale (CS). APOE genotyping conducted on cell pellet fraction. Result After accounting sex, multiple linear regression analysis revealed a significant negative association between BG‐PVS left inferior occipital gyrus (B ‐.07, 95% CI (‐.13, ‐.01), p .022), right ‐.06, (‐.12, ‐.001), .048), middle ‐.05, (‐.10, .047), ‐.08, ‐.02), .007), temporal (‐.09, .025) as well positive precuneus .05, (.01, .08), .022). When stratified by APOE4 status, all associations only carriers. CS‐PVS not CBF. Conclusion These findings indicate altered but CS‐PVS. Resting specific regions, predominantly known convey both vascular risk Alzheimer’s disease (AD). Additional longitudinal warranted explore individuals at further understand contributions development AD other dementias.