Cognitively Impaired Subjects with Normal Total Cholesterol Using Lipophilic Statins Undergo Accelerated Decline in Regions Associated with Dementia and Those Regions are Predictive of Further Decline Over the Subsequent Two‐Year Period in a Multi‐Center Longitudinal Study

• DOI: 10.1002/alz.083085
• Publication Date: 2023-12-25T15:25:40Z
• Authors: Prasanna S. Padma...; Stephen S. Liu; Daniel H. Silverman
• Keywords: Cognitive Decline; Posterior cingulate

Abstract Background We recently reported that lipophilic statins, known to penetrate the blood‐brain barrier, were associated with accelerated decline in cortical regions early Alzheimer’s Disease, subjects Mild Cognitive Impairment (eMCI) having normal cholesterol levels. now report predictive value of pattern regional metabolism forecasting severity over subsequent two years. Method Subjects drawn from a consecutive series enrolled Disease Neuroimaging Initiative, identifying 70 eMCI serum levels below 206 mg/dl median non‐statin users and clear histories time‐frames prescriptions types statins. FDG‐PET scans acquired at baseline years later compared for each group, rates metabolic determined. Result In direct statistical comparisons on voxel‐by‐voxel basis, statins (LS) underwent significantly greater posterior cingulate (PCC) right parietotemporal cortex (rPTC) those not (p<0·0005). Moreover, rPTC was positively correlated magnitude left inferior parietal LS (p = 0.008), but nonS 0.95). Conversely, either group subjects. addition, based network analysis, had functional connectivity medial temporal regions. Conclusion range taking suffered faster brain affected by disease, activity predicted further associative cortex. altered these