Clinical effects of amyloid positivity upon positron emission tomography in an Asian cohort with Alzheimer’s disease and other dementias

• DOI: 10.1002/alz.089425
• Publication Date: 2025-01-09T11:48:11Z
• Authors: Min Young Chun; Hyemin Jang; Jihwan Yun; Jun Pyo Kim; Sung Hoon Kang; Michael S. W. Weiner; Hee Jin Kim; Duk L Na; Chang‐Hyung Hong; Hyung Woong Roh; Tae‐Kyeong Lee; Eek‐Sung Lee; EUN HYE LEE; Daeun Shin; Hongki Ham; Yuna Gu; Yeshin Kim; Chi‐Hun Kim; Sook‐Young Woo; Sang Won Seo
• Keywords: Mini–Mental State Examination; Cognitive Decline

Abstract Background Ethnic differences in amyloid‐β (Aβ) characteristics and cognitive trajectories should be considered, when designing Aβ‐targeted therapies. The clinical effects of co‐pathologies Aβ have not been evaluated extensively across various dementias. We investigated the prevalence Aβ+ Koreans non‐Hispanic whites (NHWs) with Alzheimer’s syndrome (ACS) other Method included 5,856 who underwent positron emission tomography (PET) South Korea. participants were categorized into following groups: ACS, including cognitively unimpaired (CU), mild impairment (MCI), dementia Alzheimer type (DAT); subcortical vascular (SVCI); frontotemporal (FTD). Data from 929 NHWs collected Disease Neuroimaging Initiative. Mini‐Mental State Examination (MMSE) scores performed at least twice used to compare trajectories. multivariable analyses stabilized inverse probability treatment weights based on propensity mitigate imbalances ethnic groups. Result was lower CU than (odds ratio 0·6); however, this pattern observed MCI DAT stages. Moreover, stages showed a more rapid decline MMSE (CU: B= ‐0·3136, p=0·004; MCI: ‐0·3847, p<0·001). Compared CU, SVCI had higher 75–90 years age group (p<0·001). predictive decrease (B= ‐0·6424, p<0·001) but FTD. Conclusion Our findings contribute understanding biomarker traits dementias Asians highlight distinct compared NHWs.