Feasibility of Using Smartphone‐Based Cognitive Testing Among People Living with Alzheimer’s Disease and Related Dementias

• DOI: 10.1002/alz.091422
• Publication Date: 2025-01-03T14:28:27Z
• Authors: Raeanne C Moore; Kevin Kuehn; Diviya Khullar; Carissa Jantz; Jessie M Song; Prasanna Padmanabham; Brent Mausbach; Jennifer L Martin; Yeonsu Song
• Keywords: Cognitive test; Cognitive Decline

Abstract Background Unsupervised high‐frequency cognitive‐ecological momentary assessment (EMA) on smartphones is increasingly used to assess preclinical risk for Alzheimer’s disease and related dementias (ADRD). While these tests are reliable valid individuals with ADRD, it unclear whether administering cognitive EMAs people living ADRD feasible valid. Our study explored the feasibility validity EMA in moderate severe ADRD. Method A total of 31 received web links through their care partners' smartphone three times/day seven days at baseline as part an ongoing clinical trial a dyadic sleep intervention. Of which, 23 completed any using NeuroUX platform (Quick Tap 1 [QT1], Quick 2 [QT2], Matching Pair [MP]). We examined adherence prompts, performance distributions, within‐day variability performance. also compared this data normative sample. Result On average, participants 60% (SD = 27%). This was lower than sample cognitively normal adults aged 20‐79 (N 394; mean 88%, SD 21%). Participants tapped response correctly 78.68% 0.25%) time QT1, measure psychomotor speed, took average 936.83 milliseconds 294.86) respond (see Table comparison data). inhibition (QT2), responded 33.07% items 0.19%), correct times 602.19 238.18). Finally, scored 108.08 65.60) MP, processing speed. Performance QT2 MP (% response) did not differ throughout day; however, significantly slower morning afternoon or evening (morning M 643.81; 587.14; 578.19; F (df 1) 7.24, p < 0.01). Conclusion Current findings extend research demonstrating that can be obtained from group employed research.