Attenuated neural activity in processing decision‐making feedback in uncertain conditions in patients with mild cognitive impairment

• DOI: 10.1002/alz.093395
• Publication Date: 2025-01-09T12:12:27Z
• Authors: Mang Zhang; Ying Zhang; luchun wang; Yaonan Zheng; Huizi Li; Yuhan Xie; Xiaozhen Lv; Xin Yu; Huali Wang
• Keywords: Iowa gambling task

Abstract Background Individuals with mild cognitive impairment (MCI) have decreased function, which makes them prone to making inappropriate decisions in complex and uncertain situations. However, there is currently no study being undertaken investigate the potential neural mechanisms for processing decision‐making feedback MCI patients. The present aimed explore correlates during evaluation under risk ambiguity MCI. Method Nineteen individuals twenty age‐matched HCs were enrolled. Decision‐making performance was examined modified game of dice task (GDT) an Iowa gambling (IGT). Using task‐related EEG data, reward positivity (RewP) P3 (fb‐P3) used characterize participants’ motivation allocation resources. Also, response time event‐related oscillation (ERO) evaluate information speed, potent post‐feedback integration behavioral modulation. Result patients had lower RewP (p = 0.022) fb‐P3 0.045) amplitudes GDT than HCs. Moreover, amount valence modulated 0.008; p 0.017) < 0.001; 0.001). In IGT, addition significantly reduced observed 0.010), 0.002; 0.020). Furthermore, took longer make (t 2.15, 0.041). ERO analysis revealed that delta power (GDT: 0.045; 0.011). Conclusion findings suggest that, when risky ambiguous decisions, motivation, resources, neuronal excitability attenuated It implies activity related decision compromised