The temporal onset of the core features in dementia with Lewy bodies

• DOI: 10.1002/alz.12411
• Publication Date: 2021-11-11T13:05:34Z
• Authors: Parichita Choudhury; Jonathan Graff‐Ra...; Jeremiah A. Aakre; Lincoln Wurtz; David S. Knopman; Neill R. Graff‐Ra...; Kejal Kantarci; Leah K. Forsberg; Julie A. Fields; Otto Pedraza; Qin Chen; Toji Miyagawa; Gregory S. Day; Philip Tipton; Rodolfo Savica; Hugo Botha; Christian Lachner; Brynn Dredla; R. Ross Reichard; Ronald C. Petersen; Dennis W. Dickson; Bradley F. Boeve; Tanis J. Ferman
• Keywords: Lewy body; Lewy body disease

Abstract Introduction We examined the temporal sequence of core features in probable dementia with Lewy bodies (DLB). Methods In 488 patients DLB, onset each feature and time to diagnosis was determined for men women, a pathologic subgroup (n = 209). Results REM sleep behavior disorder (RBD) developed before other women. Men were more likely have RBD diagnosed DLB earlier than Visual hallucinations after men, but they appeared concurrently fluctuations parkinsonism. Women older cognitively impaired at first visit, less RBD, be later neocortical tangles. Discussion An latency associated body disease without