Lower serum testosterone concentrations are associated with a higher incidence of dementia in men: The UK Biobank prospective cohort study

• DOI: 10.1002/alz.12529
• Publication Date: 2022-01-03T08:58:52Z
• Authors: Ross J. Marriott; Kevin Murray; Leon Flicker; Graeme J. Hankey; Alvin M. Matsumoto; Girish Dwivedi; Leen Antonio; Osvaldo P. Almeida; Shalender Bhasin; Adrian S. Dobs; David J. Handelsman; Robin Haring; Terence W. O'Neill; Claes Ohlsson; Eric S. Orwoll; Dirk Vanderschueren; Gary A. Wittert; Frederick C.W. Wu; Bu B. Yeap
• Keywords: Male; United Kingdom/epidemiology; Incidence; Middle Aged; United Kingdom; 3. Good health; Alzheimer Disease/epidemiology; 03 medical and health sciences; 0302 clinical medicine; Alzheimer Disease; Risk Factors; Sex Hormone-Binding Globulin; Humans; Testosterone; Prospective Studies; Aged; Biological Specimen Banks

Abstract Introduction The association of testosterone concentrations with dementia risk remains uncertain. We examined associations serum and sex hormone–binding globulin (SHBG) incidence Alzheimer's disease. Methods Serum total SHBG were measured by immunoassay. disease (AD) was recorded. Cox proportional hazards regression adjusted for age other variables. Results In 159,411 community‐dwelling men (median 61, followed 7 years), 826 developed dementia, including 288 from AD. Lower associated a higher (overall trend: P = .001, lowest vs highest quintile: hazard ratio [HR] 1.43, 95% confidence interval [CI] 1.13‐1.81), AD ( .017, HR 1.80, CI 1.21‐2.66). lower < 0.66, 0.51‐0.85) .012, 0.53, 0.34‐0.84). Discussion are independently incident in older men. Additional research is needed to determine causality.