Clinical reporting following the quantification of cerebrospinal fluid biomarkers in Alzheimer's disease: An international overview
[SDV.NEU.NB]Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC]/Neurobiology
Consensus approach
Clinical Neurology
610
tau Proteins
cerebrospinal fluid [Amyloid beta-Peptides]
DIAGNOSIS
RECOMMENDATIONS
Cerebrospinal fluid biomarkers
Alzheimer Disease
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CRITERIA
Humans
ddc:610
cerebrospinal fluid [Peptide Fragments]
clinical report
cerebrospinal fluid biomarkers
consensus approach
Science & Technology
Amyloid beta-Peptides
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diagnosis [Alzheimer Disease]
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Clinical report
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cerebrospinal fluid [Alzheimer Disease]
Alzheimer's disease; cerebrospinal fluid biomarkers; clinical report; consensus approach; harmonization
cerebrospinal fluid [Biomarkers]
cerebrospinal fluid [tau Proteins]
Harmonization
harmonization
Neurosciences & Neurology
Human medicine
Life Sciences & Biomedicine
Alzheimer’s disease
Biomarkers
DOI:
10.1002/alz.12545
Publication Date:
2021-12-22T12:18:10Z
AUTHORS (72)
ABSTRACT
Abstract Introduction The current practice of quantifying cerebrospinal fluid (CSF) biomarkers as an aid in the diagnosis Alzheimer's disease (AD) varies from center to center. For a same biochemical profile, interpretation and reporting results may differ, which can lead misunderstandings raises questions about commutability tests. Methods We obtained description (pre‐)analytical protocols sample reports 40 centers worldwide. A consensus approach allowed us propose harmonized comments corresponding different CSF biomarker profiles observed patients. Results procedures were similar between centers. There was considerable heterogeneity cutoff definitions report comments. therefore identified selected by most accurate informative regarding context AD diagnosis. Discussion This is first time that are proposed across worldwide specialized laboratories involved AD.
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