Mild cognitive impairment among rural‐dwelling older adults in China: A community‐based study

• DOI: 10.1002/alz.12629
• Publication Date: 2022-03-09T12:01:03Z
• Authors: Lin Cong; Yifei Ren; Yongxiang Wang; Tingting Hou; Yi Dong; Xiaojuan Han; Ling Yin; Qinghua Zhang; Jianli Feng; Lidan Wang; Shi Tang; Giulia Grande; Erika J. Laukka; Yifeng Du; Chengxuan Qiu
• Keywords: Rural Population; China; Featured Articles; Apolipoprotein E4; Middle Aged; Neuropsychological Tests; 3. Good health; Stroke; 03 medical and health sciences; Apolipoproteins E; 0302 clinical medicine; Humans; Cognitive Dysfunction; Aged

AbstractBackgroundEpidemiological studies of mild cognitive impairment (MCI) and subtypes of MCI have rarely focused on rural residents in China.MethodsThis population‐based study included 5068 participants (age ≥60 years) who were living in rural communities. We defined MCI, amnestic MCI (aMCI), and non‐amnestic MCI (naMCI) following the Petersen's criteria that integrated neuropsychological assessments with in‐person clinical evaluations.ResultsThe overall prevalence of MCI, aMCI, and naMCI was 26.48%, 22.30%, and 4.18%, respectively. The prevalence of MCI increased with age. The adjusted odds ratio (OR) of MCI was 0.71 (95% confidence interval [CI] 0.61 to 0.82) for primary school (vs. illiteracy), 0.30 (0.24 to 0.39) for middle school or above, 1.35 (1.09 to 1.67) for being farmers, 0.65 (0.54 to 0.78) for alcohol consumption, 1.43 (1.20 to 1.70) for stroke history, and 1.14 (0.95 to 1.36) for any apolipoprotein E (APOE) ε4 allele (vs ε3/ε3).ConclusionsMCI affects over one‐fourth of rural older adults in China. Overall MCI was associated with demographic factors, non‐alcohol consumption, and stroke, but not with APOE genotype and cardiometabolic factors.