Flortaucipir tau PET findings from former professional and college American football players in the DIAGNOSE CTE research project

• DOI: 10.1002/alz.13602
• Publication Date: 2023-12-22T13:58:58Z
• Authors: Yi Su; Hillary Protas; Ji Luo; Kewei Chen; Michael L. Alosco; Charles H. Adler; Laura J. Balcer; Charles Bernick; Rhoda Au; Sarah J. Banks; William B. Barr; Michael J. Coleman; David W. Dodick; Douglas I. Katz; Kenneth L. Marek; Michael D. McClean; Ann C. McKee; Jesse Mez; Daniel H. Daneshvar; Joseph N. Palmisano; Elaine R. Peskind; Robert W. Turner; Jennifer V. Wethe; Gil Rabinovici; Keith Johnson; Yorghos Tripodis; Jeffrey L. Cummings; Martha E. Shenton; Robert A. Stern; Eric M. Reiman
• Keywords: Traumatic; Male; football; 150; Football; 610; tau Proteins; flortaucipir; Middle Aged; CTE; Chronic Traumatic Encephalopathy; PET; Brain Injuries; Positron-Emission Tomography; Brain Injuries, Traumatic; Humans; Tau; Research Articles; Carbolines

AbstractINTRODUCTIONTau is a key pathology in chronic traumatic encephalopathy (CTE). Here, we report our findings in tau positron emission tomography (PET) measurements from the DIAGNOSE CTE Research Project.METHODWe compare flortaucipir PET measures from 104 former professional players (PRO), 58 former college football players (COL), and 56 same‐age men without exposure to repetitive head impacts (RHI) or traumatic brain injury (unexposed [UE]); characterize their associations with RHI exposure; and compare players who did or did not meet diagnostic criteria for traumatic encephalopathy syndrome (TES).RESULTSSignificantly elevated flortaucipir uptake was observed in former football players (PRO+COL) in prespecified regions (p < 0.05). Association between regional flortaucipir uptake and estimated cumulative head impact exposure was only observed in the superior frontal region in former players over 60 years old. Flortaucipir PET was not able to differentiate TES groups.DISCUSSIONAdditional studies are needed to further understand tau pathology in CTE and other individuals with a history of RHI.