Asian Cohort for Alzheimer's Disease (ACAD) pilot study on genetic and non‐genetic risk factors for Alzheimer's disease among Asian Americans and Canadians

• DOI: 10.1002/alz.13611
• Publication Date: 2024-01-12T18:15:01Z
• Authors: Pei‐Chuan Ho; Wai Haung Yu; Boon Lead Tee; Wan‐Ping Lee; Clara Li; Yian Gu; Jennifer S. Yokoyama; Dolly Reyes‐Dumeyer; Yun‐Beom Choi; Hyun‐Sik Yang; Badri N. Vardarajan; Marian Tzuang; Kevin Lieu; Anna Lu; Kelley M. Faber; Zoë D. Potter; Carolyn Revta; Maureen Kirsch; Jake McCallum; Diana Mei; Briana Booth; Laura B. Cantwell; Fangcong Chen; Sephera Chou; Dewi Clark; Michelle Deng; Ting Hei Hong; Ling‐Jen Hwang; Lilly Jiang; Yoonmee Joo; Younhee Kang; Ellen S. Kim; Hoowon Kim; Kyungmin Kim; Amanda B. Kuzma; Eleanor Lam; Serggio C. Lanata; Kunho Lee; Donghe Li; Mingyao Li; Xiang Li; Chia‐Lun Liu; Collin Liu; Linghsi Liu; Jody‐Lynn Lupo; Khai Nguyen; Shannon E. Pfleuger; James Qian; Winnie Qian; Veronica Ramirez; Kristen A. Russ; Eun Hyun Seo; Yeunjoo E. Song; Maria Carmela Tar...; Lu Tian; Mina Torres; Namkhue Vo; Ellen C. Wong; Yuan Xie; Eugene B. Yau; Isabelle Yi; Victoria Yu; Xiaoyi Zeng; Peter St George‐H...; Rhoda Au; Gerard D. Schelle...; Jeffrey L. Dage; Rohit Varma; Ging‐Yuek R. Hsiung; Howard Rosen; Victor W. Henderson; Tatiana Foroud; Walter A. Kukull; Guerry M. Peavy; Haeok Lee; Howard H. Feldman; Richard Mayeux; Helena Chui; Gyungah R. Jun; Van M. Ta Park; Tiffany W. Chow; Li‐San Wang
• Keywords: Aging; Canada; Biological Psychology; Clinical Sciences; Clinical Trials and Supportive Activities; 610; Clinical sciences; Pilot Projects; Neurodegenerative; Alzheimer's Disease; environmental; Environmental; 03 medical and health sciences; 0302 clinical medicine; Clinical Research; Alzheimer Disease; Risk Factors; Genetics; Acquired Cognitive Impairment; Psychology; Humans; Minority Health; genetics; Research Articles; community-based participatory research; Community-based participatory research; Biomedical and Clinical Sciences; Asian; North American People; Prevention; Neurosciences; Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD); Alzheimer's disease; Biosamples; Brain Disorders; Health Disparities; Geriatrics; Neurological; Biological psychology; Dementia; biosamples; 2.4 Surveillance and distribution; dementia

AbstractINTRODUCTIONClinical research in Alzheimer's disease (AD) lacks cohort diversity despite being a global health crisis. The Asian Cohort for Alzheimer's Disease (ACAD) was formed to address underrepresentation of Asians in research, and limited understanding of how genetics and non‐genetic/lifestyle factors impact this multi‐ethnic population.METHODSThe ACAD started fully recruiting in October 2021 with one central coordination site, eight recruitment sites, and two analysis sites. We developed a comprehensive study protocol for outreach and recruitment, an extensive data collection packet, and a centralized data management system, in English, Chinese, Korean, and Vietnamese.RESULTSACAD has recruited 606 participants with an additional 900 expressing interest in enrollment since program inception.DISCUSSIONACAD's traction indicates the feasibility of recruiting Asians for clinical research to enhance understanding of AD risk factors. ACAD will recruit > 5000 participants to identify genetic and non‐genetic/lifestyle AD risk factors, establish blood biomarker levels for AD diagnosis, and facilitate clinical trial readiness.HIGHLIGHTS The Asian Cohort for Alzheimer's Disease (ACAD) promotes awareness of under‐investment in clinical research for Asians. We are recruiting Asian Americans and Canadians for novel insights into Alzheimer's disease. We describe culturally appropriate recruitment strategies and data collection protocol. ACAD addresses challenges of recruitment from heterogeneous Asian subcommunities. We aim to implement a successful recruitment program that enrolls across three Asian subcommunities.