Harmonizing tau positron emission tomography in Alzheimer's disease: The CenTauR scale and the joint propagation model

• DOI: 10.1002/alz.13908
• Publication Date: 2024-07-23T10:47:04Z
• Authors: Antoine Leuzy; Lars Lau Raket; Victor L. Villemagne; Gregory Klein; Matteo Tonietto; Emily Olafson; Suzanne Baker; Ziad S. Saad; Santiago Bullich; Brian Lopresti; Sandra Sanabria B...; Mercè Boada; Tobey J. Betthauser; Arnaud Charil; Emily C. Collins; Jessica A. Collins; Nicholas Cullen; Roger N. Gunn; Makoto Higuchi; Eric Hostetler; R. Matthew Hutchison; Leonardo Iaccarino; Philip S. Insel; Michael C. Irizarry; Clifford R. Jack; William J. Jagust; Keith A. Johnson; Sterling C. Johnson; Yashmin Karten; Marta Marquié; Sulantha Mathotaa...; Mark A. Mintun; Rik Ossenkoppele; Ioannis Pappas; Ronald C. Petersen; Gil D. Rabinovici; Pedro Rosa‐Neto; Christopher G. Sc...; Ruben Smith; Andrew W. Stephens; Alex Whittington; Maria C. Carrillo; Michael J. Pontec...; Samantha Budd Hae...; Billy Dunn; Hartmuth C. Kolb; Sudhir Sivakumaran; Christopher C. Rowe; Oskar Hansson; Vincent Doré
• Keywords: Male; Aging; [18F]MK‐6240; Biological Psychology; [18F]PI‐2620; Clinical sciences; head-to-head; Neurodegenerative; [F-18]Flortaucipir; Alzheimer's Disease; [F-18]RO948; [18F]GTP1; Imaging; Cohort Studies; Models; Psychology; tau; CPAD; Brain; [F-18]GTP1; Statistical; Alzheimer's disease; CenTauR; [18F]RO948; Neurological; Biomedical Imaging; Female; Research Article; Clinical Sciences; 610; Bioengineering; tau Proteins; C-Path; Alzheimer Disease; 616; Acquired Cognitive Impairment; C‐Path; Humans; [F-18]PI-2620; Centiloid; head‐to‐head; Aged; standardization; Models, Statistical; Neurosciences; Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD); [18F]Flortaucipir; Brain Disorders; [F-18]MK-6240; PET; Geriatrics; Positron-Emission Tomography; Biological psychology; Dementia; Radiopharmaceuticals

Abstract INTRODUCTION Tau‐positron emission tomography (PET) outcome data of patients with Alzheimer's disease (AD) cannot currently be meaningfully compared or combined when different tracers are used due to differences in tracer properties, instrumentation, and methods analysis. METHODS Using head‐to‐head from five cohorts tau PET radiotracers designed target deposition AD, we tested a joint propagation model (JPM) harmonize quantification (units termed “CenTauR” [CTR]). JPM is statistical that simultaneously models the relationships between anchor point data. was linear regression approach analogous one amyloid Centiloid scale. RESULTS A strong relationship observed CTR values across brain regions. approach, estimates were similar to, but more accurate than, those derived using approach. DISCUSSION Preliminary findings support development adoption universal scale for tau‐PET quantification. Highlights Tested novel PET. Units common “CenTauRs”. Centiloid‐like PET, outperformed linearregressionbased Strong CenTauRs