Association of neuroticism with incident dementia, neuroimaging outcomes, and cognitive function

• DOI: 10.1002/alz.14071
• Publication Date: 2024-07-10T11:36:49Z
• Authors: Yaqing Gao; Najaf Amin; Cornelia van Duijn; Thomas J Littlejohns
• Keywords: Vascular dementia

Abstract INTRODUCTION Higher neuroticism might be associated with dementia risk. Here we investigated modification by genetic predisposition to dementia, mediation mental health and vascular conditions, neuroimaging outcomes, cognitive function. METHODS Cox proportional‐hazards models were used assess the association between score incident over up 15 years in 1,74,164 participants. Cross‐sectional analyses on dementia‐related outcomes function conducted 39,459 dementia‐free RESULTS was an 11% higher risk of especially (15% risk), regardless dementia. Mental conditions mediated all‐cause Neuroticism cerebrovascular pathology, lower gray matter volume, worse across multiple domains. DISCUSSION could represent a factor for drive these associations. Highlights increased particularly Associations not modified largely conditions. pathology volume.