Effects of a multidomain intervention against cognitive decline on dementia risk profiles — Results from the AgeWell.de trial

• DOI: 10.1002/alz.14097
• Publication Date: 2024-07-05T11:34:31Z
• Authors: Andrea E. Zülke; Alexander Pabst; Melanie Luppa; Anke Oey; Solveig Weise; Thomas Fankhänel; Robert P. Kosilek; Hannah Schillok; Christian Brettsc...; David Czock; Birgitt Wiese; Jochen René Thyrian; Wolfgang Hoffmann; Thomas Frese; Jochen Gensichen; Hans‐Helmut König; Hanna Kaduszkiewicz; Steffi G. Riedel‐...
• Keywords: Male; lifestyle; epidemiology [Dementia]; prevention & control [Dementia]; prevention; risk factor; Risk Factors; Hypertension; randomized controlled trial; Humans; prevention & control [Cognitive Dysfunction]; Female; ddc:610; Life Style; Risk Reduction Behavior; Aged; dementia; Research Article

AbstractINTRODUCTIONDementia risk scores constitute promising surrogate outcomes for lifestyle interventions targeting cognitive function. We investigated whether dementia risk, assessed using the LIfestyle for BRAin health (LIBRA) index, was reduced by the AgeWell.de intervention.METHODSSecondary analyses of the AgeWell trial, testing a multicomponent intervention (including optimization of nutrition, medication, and physical, social, and cognitive activity) in older adults with increased dementia risk. We analyzed data from n = 461 participants with complete information on risk/protective factors comprised by LIBRA at the 24‐month follow‐up. Intervention effects on LIBRA and LIBRA components were assessed using generalized linear models.RESULTSThe intervention reduced LIBRA scores, indicating decreased dementia risk at follow‐up (b = –0.63, 95% confidence interval [CI]: –1.14, –0.12). Intervention effects were particularly due to improvements in diet (odds ratio [OR]: 1.60, 95% CI: 1.16, 2.22) and hypertension (OR: 1.61, 95% CI: 1.19, 2.18).DISCUSSIONThe AgeWell.de intervention reduced dementia risk. However, several risk factors did not improve, possibly requiring more intensive interventions.Highlights The AgeWell.de intervention reduced dementia risk according to LIfestyle for BRAin health (LIBRA) scores. Beneficial effects on LIBRA are mainly due to changes in diet and blood pressure. A pragmatic lifestyle intervention is apt to reduce dementia risk in an at‐risk population.