Bridging the gap: Multi‐omics profiling of brain tissue in Alzheimer's disease and older controls in multi‐ethnic populations

• DOI: 10.1002/alz.14208
• Publication Date: 2024-08-31T06:33:10Z
• Authors: Joseph S. Reddy; Laura Heath; Abby Vander Linden; Mariet Allen; Katia de Paiva Lopes; Fatemeh Seifar; Erming Wang; Yiyi Ma; William L. Poehlman; Zachary S. Quicksall; Alexi Runnels; Yanling Wang; Duc M. Duong; Luming Yin; Kaiming Xu; Erica S. Modeste; Anantharaman Shan...; Eric B. Dammer; Lingyan Ping; Stephanie R. Oatman; Jo Scanlan; Charlotte Ho; Minerva M. Carras...; Merve Atik; Geovanna Yepez; Adriana O. Mitchell; Thuy T. Nguyen; Xianfeng Chen; David X. Marquez; Hasini Reddy; Harrison Xiao; Sudha Seshadri; Richard Mayeux; Stefan Prokop; Edward B. Lee; Geidy E. Serrano; Thomas G. Beach; Andrew F. Teich; Varham Haroutunian; Edward J. Fox; Marla Gearing; Aliza Wingo; Thomas Wingo; James J. Lah; Allan I. Levey; Dennis W. Dickson; Lisa L. Barnes; Philip De Jager; Bin Zhang; David Bennett; Nicholas T. Seyfried; Anna K. Greenwood; Nilüfer Ertekin‐T...
• Keywords: Omics; Profiling (computer programming); Cognitive Decline

Abstract INTRODUCTION Multi‐omics studies in Alzheimer's disease (AD) revealed many potential pathways and therapeutic targets. Despite their promise of precision medicine, these lacked Black Americans (BA) Latin (LA), who are disproportionately affected by AD. METHODS To bridge this gap, Accelerating Medicines Partnership Disease (AMP‐AD) expanded brain multi‐omics profiling to multi‐ethnic donors. RESULTS We generated data curated harmonized phenotypic from BA ( n = 306), LA 326), or 4) donors plus non‐Hispanic White 252) other 20) ethnic groups, establish a foundational dataset enriched for participants. This study describes the available research community, including transcriptome three regions, whole genome sequence, proteome measures. DISCUSSION The inclusion traditionally underrepresented groups is essential discovering full spectrum medicine targets that will be pertinent all populations with Highlights Diversity Initiative led tissue populations. Brain American, RNA, sequencing tandem mass tag proteomicsis completed shared. Multiple regions caudate, temporal dorsolateral prefrontal cortex were profiled.