Microglial responses partially mediate the effect of Aβ on cognition in Alzheimer's disease

• DOI: 10.1002/alz.14298
• Publication Date: 2024-10-11T11:04:20Z
• Authors: Lasse S. Madsen; Rola Ismail; Peter Parbo; Pernille L. Kjeldsen; Jeppe L. Schaldemose; Kim V. Hansen; Hanne Gottrup; Joel Aanerud; Simon F. Eskildsen; David J. Brooks
• Keywords: Amyloid beta; Cognitive Decline; Association (psychology)

Abstract INTRODUCTION Microglial responses are an integral part of Alzheimer's disease (AD) pathology and associated with amyloid beta (Aβ) deposition. This study aimed to investigate the effects Aβ microglial on global cognitive impairment. METHODS In this longitudinal study, 28 patients mild impairment 11 healthy controls underwent C‐PK11195 C‐Pittsburgh compound B positron emission tomography (PET), structural magnetic resonance imaging scans, ratings at baseline 2‐year follow‐up. Correlations between PET uptake cognition were assessed. Additionally, mediation effect response association load was RESULTS both independently detrimental performance baseline; however, follow‐up partially mediated by response. DISCUSSION As AD progresses, mediates aggregated cognition. Highlights a (Aβ), responses, performance. affect in early disease. later stages.