Plasma Alzheimer's disease biomarker variability: Amyloid‐independent and amyloid‐dependent factors

• DOI: 10.1002/alz.14368
• Publication Date: 2024-11-13T12:38:52Z
• Authors: Eun Hye Lee; Sung Hoon Kang; Daeun Shin; Young Ju Kim; Henrik Zetterberg; Kaj Blennow; Fernando Gonzalez...; Nicholas J. Ashton; Bo Kyoung Cheon; Heejin Yoo; Hongki Ham; Jihwan Yun; Jun Pyo Kim; Hee Jin Kim; Duk L. Na; Hyemin Jang; Sang Won Seo
• Keywords: Amyloid (mycology); β amyloid

We aimed to investigate which factors affect plasma biomarker levels via amyloid beta (Aβ)-independent or Aβ-dependent effects and improve the predictive performance of these biomarkers for Aβ positivity on positron emission tomography (PET). A total 2935 participants underwent blood sampling measurements Aβ42/40 ratio, phosphorylated tau 217 (p-tau217; ALZpath), glial fibrillary acidic protein (GFAP), neurofilament light chain (NfL) using single-molecule array PET. Laboratory findings were collected a routine test battery. Aβ-independent included hemoglobin estimated glomerular filtration rate (eGFR) p-tau217 hemoglobin, eGFR, triiodothyronine (T3) GFAP NfL. apolipoprotein E genotypes, body mass index status Aβ42/40, p-tau217, GFAP, However, exhibited negligible modest Our highlight importance accurately interpreting predicting uptake in real-world settings. investigated factor-Alzheimer's disease associations large Korean cohort. Hemoglobin independently brain (Aβ). Apolipoprotein genotypes dependent Aβ. Addition shows effect positivity. Adjusting